Patients in these studies had a median (interquartile range) age of 54 (43-65) years, and 3026 (59%) were men. Main Outcomes and Measures The outcome measures were the trend in BAI when moving from groups ranging from healthy, to symptomatic, to MCI, to dementia and pairwise comparisons of BAI among these groups.įindings A total of 5144 sleep studies were included in BAI examinations. Data were analyzed from November 15, 2018, to June 24, 2020.Įxposure Dementia, MCI, and dementia-related symptoms, such as cognitive change and memory impairment. Objective To investigate the association between a sleep electroencephalography-based brain age index (BAI), the difference between chronological age and brain age estimated using the sleep electroencephalogram, and dementia.ĭesign, Setting, and Participants In this retrospective cross-sectional study of 9834 polysomnograms, BAI was computed among individuals with previously determined dementia, mild cognitive impairment (MCI), or cognitive symptoms but no diagnosis of MCI or dementia, and among healthy individuals without dementia from August 22, 2008, to June 4, 2018. A biomarker for dementia that can identify individuals with or at risk for developing dementia may help close this diagnostic gap. Importance Dementia is an increasing cause of disability and loss of independence in the elderly population yet remains largely underdiagnosed. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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